Cancer Research UK Jobs

Senior Principal Scientist, Enzymology

Application Deadline: 26 January 2025 23:55

Cambridge, Babraham Research Campus or Glasgow, CRUK Scotland Institute

We seek to recruit a passionate individual to lead and drive our Mechanistic Enzymology strategy, based at our Babraham Research Campus facilities in Cambridge, or CRUK Scotland Institute facilities in Glasgow. This is an exciting opportunity & time to join us as we move forwards with our new strategy and 5-year plan.

About CRUK drug discovery

At Cancer Research UK, our focus is on beating cancer. As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.

We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of world class biology, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.

Based at 3 sites in Cambridge (Babraham Research Campus, the Biomedical Campus, and Granta Park), together with the CRUK Scotland Institute in Glasgow, the Francis Crick Institute in London, and Newcastle University, Cancer Research Horizons employs ~200 staff from both industrial and academic backgrounds.

We bring together the best minds in basic and clinical cancer research, the diligence and drive of pharmaceutical and biotech companies, and our in-house drug discovery capabilities to deliver breakthrough medicines for cancer patients.

Our laboratories house the personnel and state of the art equipment required to progress projects from initial hypothesis through to selection of candidate drugs for regulatory development. We couple this with a deep understanding of academic and industrial drivers, enabling us to progress projects that combine the curiosity of basic research and the rigour of drug discovery.

Who we are looking for

Our new strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from Idea to pre-clinical Candidate. Reporting directly to the SVP Drug Discovery, you will set the vision and lead our mechanistic enzymology strategy, helping to identify the right drugs with the right mechanisms for the right patients, faster. You will also play a Leadership role in the wider Molecular Sciences department, contributing to the strategic direction within CRH.

As our Senior Principal Scientist (SPS) Enzymology, you will be an inspirational scientist with an exceptional record of bringing your deep knowledge of enzymology and drug-target kinetics to impact on projects. You will be an experienced and passionate scientific leader, able to represent the department across a broad range of therapeutic projects and cross-site initiatives, and externally. You will contribute to, and lead, specific areas of scientific and technical innovation (including in novel modalities aligned to our strategic direction), incorporating external collaboration and partnership along with internal science builds. You will also lead drug discovery projects. Whilst this role will not manage any direct line-reports, a significant element will involve matrix leadership; you will also play a pivotal role in training and developing colleagues, including through your practical contributions from the bench.

We are seeking an accomplished scientific leader who can articulate a vision for our mission and set direction and inspire commitment for preclinical Discovery. The SPS should have the following skills:

• Deep expertise in classical mechanistic enzymology and its role in drug discovery

• Ability to provide Scientific and Strategic leadership for the Molecular Sciences department, and wider CRH, to drive innovation and portfolio success

• Confidence and credibility to work at the intersection between mechanistic pharmacology, medicinal chemistry, computational chemistry, structural biology & DMPK to define and prosecute strategies that deliver mechanistic insight across a range of challenging target classes, from initial target characterisation through to clinical dose prediction

• Proactive, future-orientated and strategic in thinking style

• Excellent communication skills, ability to influence multiple stakeholders and collaborate across projects and sites

• A passion for promotion of scientific excellence, through external publication, presentations, and membership of conference committees and Scientific Advisory Boards

• Ensure equality and diversity is celebrated and considered as part of all decisions taken

• Excellent team-working skills combined with broad cross-functional knowledge

Essential Requirements

Education:

PhD in Enzymology, Pharmacology, or equivalent experience

Significant experience and deep expertise in mechanistic enzymology in a drug discovery environment

Experience

• Proven track record of innovative scientific delivery through driving impactful mechanistic enzymology insight in drug discovery programmes, including detailed characterisation of multi-substrate enzyme mechanisms and drug mechanism-of-action

• Significant experience in translating drug-target kinetics from the molecular and cellular levels through to mechanistic PKPD modelling for therapeutic dose prediction

• Proven track record of portfolio impact across a range of challenging target classes, through intellectual and laboratory-based contributions, and project leadership

• Strong external reputation in mechanistic enzymology and drug discovery, evidenced through wide personal network, external presentation and publication in high-impact journals, and influential roles on relevant external committees

• Significant experience in inspiring and developing a diverse world-class group, whilst working in a highly matrixed discovery project environment

• Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects

• Track record of delivering results across a diverse project portfolio by proactively driving strategic and scientific initiatives

What we can offer you

• Competitive benefits package. Starting Salary £67,200 - £76,000 K subject to experience and negotiable

• Option to access the CRUK pension scheme where CRUK will contribute up 12% of your salary.

• Opportunities for professional development and conference attendance.

• A beautiful setting to work in, with access to campus facilities such as gym, tennis court, on site restaurant and country walks.

• Being part of a vibrant team committed to beating cancer.

Big ideas. Lifelong connections. One objective. 

Marketing Rules and Contact Manager

(Internally this role is known as Marketing Rules and Contactability Manager)

£40,000 - £45,000 plus TBC waiting update from reward

Reports to: Head of Digital

Directorate: Marketing, Fundraising & Engagement

Contract: Permanent

Hours: Full time 35 hours per week

Location: Stratford, London Office-based with high flexibility (1-2 days per week in the office)

Closing date: 26 January 2025 23:55

This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. Please let us know if there is anything about the recruitment process that you would like to discuss, in particular if there are any changes or adjustments that would make it easier for you to apply. Please contact or 020 3469 8400 as soon as possible.

Visa sponsorship: You must be eligible to work in the UK to apply for this vacancy. Cancer Research UK is not able to offer visa sponsorship.

Recruitment process: Competency interview via Teams

At Cancer Research UK, we exist to beat cancer.

We're proud of how many people choose to support Cancer Research mission. However, to grow our funding we must build even greater momentum and urgency around our cause, and engage people in much deeper, more meaningful ways. This is the vision behind the of our strategy as we work to deliver seamless online and offline interactions, and a service that is personal to our audiences.

By continually finding new and better ways to connect with people, through personalised marketing, we will be able to understand what our audiences value, so we are there with the right offer at the right time when someone is ready to act.

To support our vision, we are bringing together our digital capabilities into one team within marketing & digital. We are currently recruiting a Marketing Rules and Contactability Manager. This person will be responsible for the cross-organisational owned channel marketing rules, establishing best practice and expertise in below the line marketing delivery including email, SMS, Direct Mail and Telemarketing.

We are looking for someone with demonstrable experience of defining customer contact strategies to increase customer engagement, loyalty and satisfaction. So whether you are a Customer Loyalty Manager, CRM Manager or Lifecycle Manager and have solid experience within below the line marketing (specifically direct mail, SMS, telemarketing and email) we would love to hear from you.

This is a great opportunity to play a key role in one of CRUKs biggest transformation programme, one where you will be able to see tangible results of your work and the impact it has on supporting our mission

What will I be doing?

• Creates and maintains the direct contact marketing calendar (including email, SMS, and direct mail) in alignment with the overall marketing calendar set by Marketing Planning.

• Manage and iterate the cross-organisational supporter contact strategy and work with key stakeholders to ensure buy-in for this across all areas of the charity.

• Review and update the contact model when needed working with key teams such as Data Security to ensure it is aligned with our data governance policy.

• Identify and explore new opportunities to increase the contactable supporter base. This will include understanding new potential data sources and working with relevant teams across CRUK to identify supporters we are not contacting.

• Lead the requirement gathering for any new contactable supporter initiatives such as lead generation

• Identify opportunities to communicate with supporters in innovative ways to drive engagement and loyalty and for new lead generation opportunities.

• Work closely with the Technology team to resource and deliver the changes required to underpin a supporter-centric approach to strategic marketing planning and delivery.

• Work with data and insight experts to ensure we are effectively using data to target the right individuals with the right message at the right time.

What are you looking for?

• Proven track record in below the line marketing / CRM

• Significant understanding of end-to-end supporter/Customer journeys and the role of different marketing channels in fully integrated campaigns, with the ability to think about bigger picture priorities and translate strategy into operational planning and delivery

• Understanding of marketing permissions landscape and governance

• Ability to build collaborative relationships and influence stakeholders at all levels.

• Significant project management experience with a proven ability to manage multiple priorities, deadlines and objectives effectively, with a flexible approach to adapt to changing priorities.

• Strong analytical skills with a proven ability of evaluating, interpreting and drawing insight from data then taking appropriate action

Our organisation values are designed to guide all that we do.

Bold: Act with ambition, courage and determination

Credible: Act with rigour and professionalism

Human: Act to have a positive impact on people

Together: Act inclusively and collaboratively

We're looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.

If you're interested in applying and excited about working with us but are unsure if you have the right skills and experience we'd still love to hear from you.

What will I gain?

We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.

You can explore our benefits by visiting our .

How do I apply?

We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.

For more information on this career opportunity please or contact us at .

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